The biological system of the physical body is completely amazing. The organic ensemble of fibers, nerve endings, tissues, and whatnot are so complicated and within the right situation, is totally capable of restoring itself. Most of it’s thanks to the endocannabinoid system present in each and each mammal on the earth. The brain forms also a part of this equation and therefore the adult brain can produce new neurons. This process is named neurogenesis.
Neurogenesis mostly takes part in two parts of the brain. It takes place within the subventricular zone (SVZ) and therefore the subgranular zone (SGZ). Neurogenesis is vitally important within the adult brain because it regulates mood, brain health, and learning. Some psychiatric disorders are believed to be associated with impaired neurogenesis.
Brain Injury and Damage spark Healing: Whenever the brain gets injured by either a significant accident or small bumps, the Neuro Stem and Progenitor Cells (NSPC) are influenced by several internal and external aspects. the speed of how briskly healing will happen is controlled by these factors. Things like lineage differentiation, proliferation, maturation, migration, and survival are subject to those controls. When these aspects are clearly understood, simpler therapeutic ways and medications might be on the table to hurry up the healing process. The brain is usually doing its part and can always tempt to hurry to heal along. Understanding the way to contribute is what researchers are performing on non- stop.
Where does the Endocannabinoid System come in?
The endocannabinoid system with its own cannabinoid molecules and receptors are found everywhere the body. they’re found within the brain also because the system . they’re also present in organs, skin, and tissues of your body. In any injury, the endocannabinoid system ignites the assembly of endocannabinoids and receptors to assist within the healing process. Therefore, it’s concluded that the endocannabinoid system also helps with neural regeneration. In certain scientific tests, where the CB1 receptors of mice were blocked, neurogenesis significantly reduced. The tests were confirmed in vitro when neural cells, growth, and division of neuro progenitor cells were constrained when the CB1 and CB2 receptors were blocked.
Since the legalization of Cannabis, more studies were done on the role of cannabinoids in neurogenesis thanks to the multiplicity of neuro-modulatory functions. The CB1 and CB2 receptors regulate adult neurogenesis by intervening at specific neurogenic phases. When CB1 and CB2 receptors were activated by specific agonists, it regulates cell proliferation, maturation, and neural differentiation.
There’s definite interaction between the Brain-Derived Neurotrophic Factors (BDNF) and endocannabinoid signaling. The interaction triggers a release of endocannabinoids at cortical excitatory synapsis. this suggests that the endocannabinoid system and cannabinoids derived from cannabis work alongside the BDNF to fine-tune neurogenesis.
THC administration before Brain Injury: Clinical studies show that THC has neuroprotective abilities when it’s administered before traumatic brain injuries. In fact, regular cannabis consumers with a positive THC screen showed decreased cell mortality. THC can provide impairment protection to the brain if taken before an injury.
CBD Speeds Neurogenesis Up: Cannabidiol or CBD features a positive effect on neurogenesis. Brain damage provoked by stress and anxiety benefits from CBD because it reduces neurogenesis. Because CBD is taken in small amounts, the effect it not immediately. There are high levels of CB1 and CB2 receptors within the brain where Neuron progenitor cells are found and where neuron growth and differentiation are promoted. The enzymes helping the endocannabinoid arachidonoylglecerol (2-AG), also are during this a part of the brain. it’s just another confirmation that the endocannabinoid system is a component of neurogenesis. Both the cannabinoid receptors are involved and when the signaling pathways are activated by the cannabinoids, it motivates the neuron progenitor cells to grow and divide.
Cannabinoids Maintain Cellular Health: Where’s sufficient growth of neuron progenitor cells, they migrate to the various parts of the brain. this is often called differentiation. they modify into the sort of cell the brain needs at the time. Cannabinoids are intricate during this process also. When differentiation is complete, the CB receptors remain there. Their role is to signal if the cell must live, should receive cell maintenance, or should be subjected to programmed necrobiosis.